|
KMID : 0379520050210040279
|
|
한국독성학회지
2005 Volume.21 No. 4 p.279 ~ p.284
|
|
|
Protective Activity Against Oxidative Stress of Plants Indigenous to Korea
|
|
Jung Myung-Sun
Kang Kyung-Ah
Zhang Rui
Chae Sung-Wook
Yoo Byung-Sam
Yang Young-Taek
Lee Nam-Ho
Park Jae-Woo
Hyun Jin-Won
|
|
|
Abstract
|
|
|
|
We have screened the cytoprotective effect against H_2O_2 and gamma-ray radiation induced oxidative stress from 32 Korean plants. Betula ermani var.saitoana (caulis, leaves), Rosa wichuraiana (caulis), Sorbus commixta (caulis), Weigela florida (leaves), Cirsium rhinoceros (whole plant), and Viburnum erosum (caulis) were found to scavenge 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical and intracellular reactive oxygen species (ROS). As a result, extracts of six plants reduced cell death of Chinese hamster lung fibroblast (V79-4) cells induced by H_2O_2 treatment. In addition, these extracts protected cell death of V79-4 cells damaged by gamma-ray radiation. In addition, these extracts scavenged ROS generated by radiation. Taken together, the results suggest that Betula ermani var. saitoana, Rosa wichuraiana, Sorbus commixta, Weigela florida, Cirsium rhinoceros, and Vibumum erosum protect V79-4 cells against oxidative damage by radiation through scavenging ROS.
|
|
|
KEYWORD
|
|
|
radiation, Oxidative stress, Reactive oxygen species
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|